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Pipeline

Therapies in Development

Our research and development teams aim to target the underlying mechanisms of brain disease. We move together towards a singular goal to deliver novel therapies that redefine the standard of care for patients and address the areas in brain disease where we see the greatest need.

Hormonal / neuropeptide signaling

Project Area Phase 1 Phase 2 Phase 3 Filing
Eptinezumab (anti-CGRP mAb)¹ Migraine prevention² Filing
Eptinezumab (anti-CGRP mAb)¹ Cluster headache 3
Lu AG09222 (anti-PACAP mAb)³ Migraine prevention² 2
Lu AG13909 (anti-ACTH mAb)⁴ Neurohormonal dysfunctions 1

Circuitry / neuronal biology

Project Area Phase 1 Phase 2 Phase 3 Filing
Brexpiprazole⁵ PTSD⁶ Filing
Lu AF28996 (D1-D2 agonist)⁷ Parkinson's disease 1
MAGLi program⁸ Neurology 1
Bexicaserin (5HT2C agonist) Developmental and epileptic encephalopathies 3

Protein aggregation, folding and clearance

Project Area Phase 1 Phase 2 Phase 3
Amlenetug (anti α-synuclein mAb) Synucleinopathies (MSA) 3

Neuroinflammation / Neuroimmunology

Project Area Phase 1 Phase 2 Phase 3
Lu AG22515 (CD40L blocker)⁹ Neurology 1

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